Karen the Hematologist describes vampirism as a disease caused by a blood-borne virus which sounds halfway logical until you think about it. A virus that makes its host tremendously strong, able heal from almost any injury and effectively immortal but which causes you to explosively disintegrate if exposed to sunlight. That is one hell of a virus!
Impossible? Not necessarily, but like the alien in ALIENS, it could never evolve naturally.*
It could only be artificial. And even then the source of energy for these abilities comes dangerously close to violating the conservation of energy, which is another way of saying it moves from science fiction to fantasy.
*It could and it did.
There's a similar virus that stops a specific type of leaf-eating Gypsy-moth caterpillar from molting, then increases moth mass via increased feeding. Caterpillars are eating machines anyway, but the virus makes the caterpillar's appetite Turbo charged.
Using this additional food, the virus increases the caterpillar's strength for climbing, its stamina for burning calories, and accelerates its ability to heal.
All good for the caterpillar, It Would Seem, but what does the virus get out of it?
On a given night, when the virus is damn good and ready, it forces the host caterpillar to climb as high as it can in a tree, hold a leaf in a death grip, and when the sun rises on the hapless caterpillar, the virus bursts from its host in an explosion which insures the virus-laden gooey bits of caterpillar will spread out and rain down on other caterpillars feeding on the leaves below, thus starting the cycle all over again. Sometimes, instead of a burst explosion, the caterpillar will melt in the sunlight.
We don't know why some melt and some explode yet, but the viral caterpillar goo dripping from the leaf and spattering below essentially achieves the same thing.
USDA: Baculovirus Molecular Biology
One of the defining characteristics of vampires is that their strength and reflexes are far superior to humans. The combination of their speed and great strength is what makes them such deadly predators.
Blade has these abilities as well, which is why he can fight vampires hand-to-hand. But Abigail and Hannibal are just ordinary human beings (well, Hannibal had an odd past but he's an ordinary human now). So I don't care how strong their Kung Fu is, they should NOT be able to get in fist fights with vampires. And yet they do, time and again, with no explanation as to how this is possible.
As far as regular science is concerned, the movie stretched my suspension of disbelief but didn't break it. I can imagine a virus that alters humans into another species with unusual abilities.
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